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A new way to look at cancer cell detection14 Jan 2013 Cancer cell detection based on the interaction between an anticancer drug and cell membrane components A novel cancer cell detection method, based on the interaction between daunomycin (DAN – an anticancer drug used in chemotherapy) and cell membrane components, has been developed by scientists in South Korea. The method uses the electrochemical and fluorescence behaviour of DAN and uses an aptamer probe immobilised on a conducting polymer-gold nanoparticle composite film. he aptamer sensor probes using electrochemical impedance spectroscopy and fluorescence microscopy. The method differentiates between cancerous and non-cancerous cells at low concentrations (0.01¥ìM). Read the ¡®HOT¡¯ Communication in full: Cancer cell detection based on the interaction between an anticancer drug and cell membrane components Pranjal Chandra , Hui-Bog Noh and Yoon-Bo Shim Chem. Commun., 2013, DOI: 10.1039/C2CC38235K 
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 | Application of a Cu–Co alloy dendrite on glucose and hydrogen peroxide sensors Hui-Bog Noh, Kyung-Sun Lee, Pranjal Chandra, Mi-Sook Won, Yoon-Bo Shim
Electrochimica Acta, Volume 61, February 2012
Abstract A Cu-Co alloy dendrite with a hierarchical nanostructure was electrochemically synthesized, and it characterized using scanning electron microscope, energy dispersive X-ray spectroscopy, time-of-flight secondary ion mass spectrometry (TOF-SIMS), X-ray diffractometery, X-ray photoelectron spectroscopy, coulometry, and cyclic voltammetry. The catalytic characteristics of the dendrite were examined for its use with highly sensitive glucose and H2O2 sensors. The TOF-SIMS image shows that the Cu-Co alloy dendrite grew homogeneously in a hierarchical structure. The Co2+ ions that formed on the alloy dendrite mainly contributed to glucose oxidation, and the Cu+ ion cooperated synergically with the Co2+ ion. However, Co3+ was mainly involved in the reduction of H2O2, while the reduction with Cu2+ ion cooperated synergically. The major oxidation products of glucose on the dendrite was confirmed to be formate (12-electron oxidation product) through coulometry and product analysis with a HPLC-MS analyzer. The linear calibration plots for the glucose and H2O2 analyses were obtained between 0.5 ¥ìM – 14.0 mM (detection limit was 0.10 ¡¾ 0.05 ¥ìM) and 1.0 ¥ìM – 11.0 mM (detection limit was 0.75 ¡¾ 0.15 ¥ìM), respectively. The performance of the final sensor was evaluated with a human blood sample. Go to Journal |
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AZoM.com : The A to Z of Materials¿¡ ÀÇÇØ¼ Thought Leaders ·Î ¼Ò°³ |
Conductive Polymers: Applications for Electronic Devices and Sensors Yoon-Bo Shim, Professor, Department of Chemistry and Director, Institute of BioPhysio Sensor Technology, Pusan National University, South Korea. Corresponding author: ybshim@pusan.ac.kr | Conductive polymers have seen great advancement during the last two decades. In general a half filled valence band, formed from a continuous delocalized ¥ð –system, is an ideal condition for conduction of electricity. However, a ¥ð –conjugated polymer can lower its energy more efficiently by bond alteration (alternating single and double bonds) and can introduce a band width of 1.5 eV making it a high energy gap semiconductor. Conducting polymers are extensively studied due to their remarkable electronic properties such as electrical conductivity, low energy optical transitions, low ionization potential, and high electron affinity. Their fundamental spectroelectrochemistry, and the applications to solar cells, biosensors, and biofuelcells have been extensively explored by our laboratory during the last decade. Some important contributions are highlighted below. |
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[ISE] The 61st Annual Meeting of The ISE / °ü¸®ÀÚ |
2010
1006 |
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Title : Electrochemistry from Biology to Physics Date : September 26 to October 1, 2010 Venue : Nice , France Paper Title : Triggering the Redox Reaction of Cytochrome c on the Biomimetic Layer and Elimination of Interferences for NADH Detection |
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[½ÉÆ÷Áö¾ö] ¹ÙÀÌ¿ÀÇÇÁö¿À¼¾¼ ¿¬±¸¼Ò / °ü¸®ÀÚ |
2010
1006 |
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Title : The 1st Symposium on BioPhysio Sensor Technology Date : 27 August, 2010 (11:00-19:30) Venue : ºÎ»ê´ëÇб³ ÈÇаü ¼¼¹Ì³ª½Ç
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[½ÉÆ÷Áö¾ö]ºÎ»ê´ë-±¸ÁÖ´ë ÇÕµ¿ ½ÉÆ÷Áö¾ö / °ü¸®ÀÚ |
2009
1209 |
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Title : ºÎ»ê´ë-±¸ÁÖ´ë ÇÕµ¿ ½ÉÆ÷Áö¾ö Date : 11 December, 2009 Venue : »ó³²±¹Á¦È¸°ü 1Ãþ |
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[½ÉÆ÷Áö¾ö]The Second Japan-Korea Joint Symposium~ / °ü¸®ÀÚ |
2009
1009 |
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Title : The Second Japan-Korea Joint Symposium on Bio-microsensing Technology Contents : Increasing Importance of Bio-microsensing Technology in Medical and Dental Areas Date : 13 November, 2009 Venue : Tobata campus, Room 8-1A, Kyushu Institute of Technology (Kyutech), Kitakyushu, Japan This symposium aims to enhance high-level academic exchanges of ideas on the development of various state-of-the-art technologies on biochips and related subjects connected with medical and dental areas. The Organizing Committee hopes that this symposium will become important bridge between Japan and Korea through biochip technologies. |
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Á¦ 6ȸ ºÎ»ê°úÇбâ¼ú»ó - °úÇкι® ½ÉÀ±º¸ ºÎ»ê´ë±³¼ö / °ü¸®ÀÚ |
2007
0420 |
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±¹Á¦½Å¹®°ú ºÎ»ê°úÇбâ¼úÇùÀÇȸ´Â 19ÀÏ Á¦6ȸ ºÎ»ê°úÇбâ¼ú»ó ¼ö»óÀÚ·Î °úÇлóºÐ¾ß¿¡ ½ÉÀ±º¸(ºÎ»ê´ë ÈÇÐ) ±³¼ö ¸¦ ¼±Á¤Çß´Ù. °úÇлóÀ» ¹Þ°Ô µÈ ½ÉÀ±º¸(ºÎ»ê´ë ÈÇаú) ±³¼ö´Â Àü±â ºÐ¼®ÈÇÐ ¹× ¹ÙÀÌ¿À ÈÇÐ ¼¾¼ °ü·Ã ºÐ¾ß¿¡¼ ¹Ì±¹ ÈÇÐȸ ¹× ¿µ±¹ ¿Á½ºÆÛµå ÃâÆÇ SCI±Þ ³í¹® 120¿© ÆíÀ» Æ÷ÇÔ, ±¹³»¿Ü ÃÑ 200¿© ÆíÀÇ ³í¹®À» ¹ßÇ¥ÇÏ¿© ÁúÀû ¾çÀûÀ¸·Î ¼¼°è ÃÖ°í¼öÁØÀÇ ¿¬±¸¾÷ÀûÀ» ´Þ¼ºÇß´Ù. ±¹³»¿Ü ƯÇã 20¿©°ÇÀ» Æ÷ÇÔÇØ ÈÇм¾¼ ¹× ºÐ¼®±â ±â¼úÀ» »ç¾÷ÈÇÏ¿´°í, ÃÖ±Ù¿¡´Â ¹Ì±¹¿¡ ÀüÀ§Â÷ ÃøÁ¤ Àåºñ¸¦ ¼öÃâÇÏ´Â µî »ê¾÷Àû ±â¿©°¡ ÄÇ´Ù. "°úºÐÇϰԵµ Á¦°¡ ºÎ»ê°úÇбâ¼ú»óÀ» ¹Þ°Ô µÈ °ÍÀº Áö±Ý±îÁö Àú¿Í ÇÔ²² ¿¬±¸¿¡ ¸ôµÎÇØ ÁֽŠÁÖÀ§ÀÇ ¿©·¯ ±³¼ö´Ô°ú ´ëÇпø»ýµé ´öºÐÀ̶ó »ý°¢Çϸç, ±×ºÐµé²² °¨»çµå¸³´Ï´Ù. ¶ÇÇÑ Å« »óÀ» ÈÄ¿øÇØ ÁֽŠºÎ»ê±¤¿ª½Ã¿Í ºÎ»ê°úÇбâ¼úÇùÀÇȸ ¹× ½É»çÀ§¿ø´Ôµé²²µµ °¨»çÀÇ ¸»¾¸À» ÀüÇÕ´Ï´Ù.
ºÎ»ê¿¡¼ ž°í ¼ºÀåÇØ ¿Â Àú·Î¼´Â ¾î¶²»óº¸´Ùµµ ºÎ»ê°úÇбâ¼ú»óÀÌ Å« Àǹ̰¡ ÀÖ½À´Ï´Ù. Àú´Â 20¿© ³â ÀüºÎÅÍ Àü±âÀüµµ¼º °íºÐÀÚÀÇ ¼ºÀå ¹× ºÐÇØ ¹ÝÀÀ ¸ÞÄ¿´ÏÁò°ú ÀüÀÚÀü´Þ ¹ÝÀÀ¿¡ ´ëÇÑ ¿¬±¸¸¦ ÅëÇØ À̵éÀÇ ºÐ¼®ÈÇÐ ¹× ¿¡³ÊÁö º¯È¯±â¼ú µîÀ» ¿¬±¸ÇØ ¿Ô½À´Ï´Ù. ¾Æ¿ï·¯ ´Ü¹éÁú È¿¼Ò DNA µî »ýü¹°Áú°ú »ýü¸·ÀÇ ÀüÀÚÀü´Þ ¹ÝÀÀ¿¡ ´ëÇÑ ÀÌÇØ, À̸¦ ÀÌ¿ëÇÑ ÈÇÐ ¹× ¹ÙÀÌ¿À¼¾¼, ÀÌÂ÷ ÀüÁö, ¹ÙÀÌ¿À ¿¬·áÀü¿¬±¸ µî¿¡ ÀúÀÇ ½Ã°£ ´ëºÎºÐÀ» ÇÒ¾ÖÇØ ¿Ô½À´Ï´Ù. ÃÖ±ÙÀÇ ´ëÇ¥Àû ¿¬±¸¼º°ú´Â Àü±âÀüµµ¼º °íºÐÀÚ¸¦ °ñ°ÝÀ¸·Î ÇÏ´Â DNA ¹× ´Ü¹éÁú ¼¾¼¿¡ ´ëÇÑ °ÍÀÔ´Ï´Ù. ÀÌ·¯ÇÑ ¿¬±¸ °á°ú°¡ »õ·Î¿î ÀÇ·á¿ë Áø´Ü¼¾¼ °³¹ß°ú »óǰȷΠ¿¬°áµÇ¾î ±¹¹Î °Ç°°ú »îÀÇ ÁúÀ» ȹ±âÀûÀ¸·Î µµ¾à½ÃŰ´Â µ¥ ÀÏÀÍÀ» ´ã´çÇÒ ¼ö Àֱ⸦ ±â´ëÇØ º¾´Ï´Ù. ±×µ¿¾È ½ÇÇè °á°ú¸¦ ¾ò±â À§ÇØ ´Ê°Ô±îÁö Çлýµé°ú ÀÛ¾÷Çϰųª ¿¬±¸½Ç¿¡¼ ³í¹®À» ÀÛ¼ºÇÏ¸é¼ ´À³¢´ø »ÑµíÇÑ °¨Á¤ÀÇ Æí¸°À¸·Î ÀÎÇØ ´ÊÀº ¹ã ¿¬±¸½Ç¿¡¼ÀÇ ¿Ü·Î¿òÀ» ¸ðµÎ ³¯·Áº¸³¾ ¼ö ÀÖ¾úÀ¾´Ï´Ù. ±×·¯³ª ¿¬±¸¿¡ ÇÊ¿äÇÑ ÀåºñµéÀ» ±¸ÀÔÇÒ ¼ö ¾ø¾î ½ÇÇèÀ» Æ÷±âÇϰųª, ¿©·¯°¡Áö Àåºñ »ç¿ë»óÀÇ Á¦¾àÀ¸·Î Áß¿äÇÑ ½ÇÇèµéÀÇ ¿¬±¸ ½Ã±â¸¦ ³õÄ£ °ÍÀº ¾Æ½¬¿òÀ¸·Î ³²½À´Ï´Ù. »óÀ» ¹Þ´Â´Ù´Â »ç½ÇÀº ´©±¸¿¡°Ô³ª ±â»Û ÀÏÀÔ´Ï´Ù. ´õ±¸³ª º»ÀÎÀÌ Æò»ýÀ» ÅõÀÚÇÑ ¿¬±¸ºÐ¾ß¿¡¼ ºÎ»ê°úÇбâ¼ú»óÀ̶ó´Â Å« »óÀ» ÁֽаÍÀº ¾ÕÀ¸·Î ´õ¿í ¿½ÉÈ÷ ÇØ Áö¼ÓÀûÀÎ ¿¬±¸ ¼º°ú¸¦ ³¾ ¼ö ÀÖµµ·Ï ³ë·ÂÇ϶ó´Â äÂïÁú·Î ¾Ë°Ú½À´Ï´Ù. »Ó¸¸ ¾Æ´Ï¶ó ÈÇÐ ¹× ¹ÙÀÌ¿À¼¾¼ ¿¬±¸ °á°ú¹°ÀÇ »ê¾÷È·Î ºÎ»êÁö¿ªÀÇ °úÇй®È ¹ßÀü»Ó ¾Æ´Ï¶ó °æÁ¦È°¼ºÈ¿¡µµ µµ¿òÀÌ µÇ±â¸¦ ¹Ù¶ó¸ç, À̹ø ¼ö»óÀÌ ¿øµ¿·ÂÀÌ µÇ¾î º¸´Ù ÈǸ¢ÇÑ ¿¬±¸ °á°ú¸¦ ¾òµµ·Ï ³ë·ÂÇϰڽÀ´Ï´Ù. °¨»çÇÕ´Ï´Ù." ¡Þ¾à·Â¡¤ÁÖ¿ä°æ·Â
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